Substances administered in Mesotherapy for Face are pharmaceutical drugs, nutrients (vitamins, minerals, amino acids), plant extracts, and homeopathic agents. Commonly used medications are vasodilators, anti-inflammatory agents, muscle relaxants, lipolysis, photolytic enzymes, vaccines, and hormones. These compounds are often combined in cocktails with or without local anesthetics (procaine or lidocaine). All medications used are FDA-approved for their use. In combination, some medicines for Mesotherapy are used for ‘off-label’ purposes. A recent illustration of this distinction is injection. Although injection was FDA approved for controlling muscle spasms, the medical community embraced it for its cosmetic properties of controlling wrinkles. For many years, plastic surgeons and dermatologists used injection for off-label purposes.
Mesotherapy treatments are typically given once per week. As improvement is seen, the treatments may be given less frequently, such as once every two weeks or once per month. The wide use of Mesotherapy, even by unqualified personnel, may be responsible for systemic and local side-effects, very often due to incorrect use of drugs and to errors in procedure. Above all this alternative medical process has been associated with the development of atypical mycobacterium infection, due to lack of aseptic measures.